Hasegawa T, et al. - In the present study, the researchers examined the age-related changes in epidermal Langerhans cells (LCs), which play a sentinel role in the initiation of the immune responses in the skin. According to findings, a significant decrease was observed in the number of epidermal LCs in the sun-protected skin with age. Findings suggested that reduced CXCL14-mediated recruitment of CD14⁺ monocytes in the human skin results in the decline of epidermal LCs with age, and CXCL14 can provide a novel therapeutic target for the prevention of age-related LC reduction.