Jia X, Li X, Li J, et al. - This study was intended to evaluate if preflushing before connecting a power injector to a patient's catheter decreases the incidence of venous air embolism (VAE) in contrast-enhanced CT angiography (CTA). In this study, a sum of 4,900 adults (control/preflushing, 2,190/2,710) were recruited and 228 (4.65%) individuals were found to have 318 VAEs (285 bubbles and 33 gas-liquid plane VAEs). The evidence showed that the incidence of VAE in the preflushing group (3.21%) was lower than that in the control group (6.44%); a similar trend was seen for multiple VAEs. No significant difference was found in the location, shape, or diameters of VAEs between the two groups. It was indicated that the recommended preflushing method is simple yet effective in decreasing the incidence of VAE by 50.16% in individuals with CTA, thus improving safety during power injection.