Panuccio V, Mallamaci F, Pizzini P, et al. - Since adherence to low salt diets and control of hypertension continue to represent unmet clinical requirements in chronic kidney disease (CKD) cases, therefore, researchers examined the impact of self-measurement of urinary chloride (69 patients) vs standard care (69 patients) on two primary outcome measures, adherence to a low sodium (Na) diet (<100 mmol/day) as determined by 24-h urine Na (UNa) excretion and 24-h ambulatory blood pressure (ABPM) monitoring in non-compliant CKD patients followed in nephrology clinics, in this 6-month multicentre randomized trial. In the active arm vs the control arm, UNa was 35 mmol/24 h lower at third month. At 6 months, there was a reduction in the between-arms difference in UNa and it was no longer significant. At 3 and 6 months, similar 24-h ABPM alterations as well as daytime and night-time BP alterations were evident between the two study arms. Overall, findings revealed that 24-h UNa was impacted modestly and 24-h ABPM was not influenced significantly by the application of self-measurement of urinary chloride to guide adherence to a low salt diet.