Hand BN, et al. – This study intends to discover how well the Pain Medication Questionnaire (PMQ) measures the risk of pain medication misuse and its precision in separating individuals with spinal cord injury (SCI) into meaningful classification categories. This study gives a deeper understanding of the measurement properties of the PMQ as a precursor for widespread population–based studies to clarify the incidence of pain medication misuse in persons with SCI. Also, results have important research and clinical implications for commonly used PMQ total score cutoffs, which may misclassify an individual’s risk of pain medication misuse.