Sukhodolsky DG, Walsh C, Koller WN, et al. - In view of the linking of activity in the supplementary motor area (SMA) with tics in Tourette syndrome (TS), researchers investigated whether a novel intervention—real-time functional magnetic resonance imaging neurofeedback from the SMA—could reduce tics in adolescents with TS via performing this first randomized controlled trial of real-time functional magnetic resonance imaging neurofeedback in 21 adolescents with TS. This study involved two sessions of neurofeedback from the SMA. They observed a significantly greater reduction of tics on the Yale Global Tic Severity Scale after real neurofeedback among participants compared with the sham control. With respect to the findings, this neurofeedback intervention seems valuable for improving tic symptoms. However, there appeared no effects in terms of change in control over the SMA, the hypothesized mechanism of action.