Tobah YSB, et al. - The acceptability and effectiveness of OB Nest, a reduced frequency prenatal care model enhanced with remote home monitoring devices and nursing support, were determined in this single center randomized controlled trial. In this trial 300 pregnant women (< 13 weeks gestation), age 18 to 36 years, recruited from an outpatient obstetric tertiary academic center in the Midwest, United States were randomized to OB Nest or usual care (150 in each arm) using a minimization algorithm. In OB Nest care, 8 onsite appointments with an obstetric provider, 6 virtual visits consisting of phone or online communication with an assigned nurse, supplemented with fetal Doppler and sphygmomanometer home monitoring devices, and access to an online community of pregnant women were included. While 12 pre-scheduled prenatal clinic appointments with obstetric providers were included in usual care. As per outcomes, OB Nest is supported as an innovative, acceptable and effective reduced frequency prenatal care model. The model resulted in higher patient satisfaction and lower prenatal stress compared to routine prenatal care, while decreasing the number of appointments with clinicians and maintaining care standards for pregnant women.