Sahu P, Kedia S, Vuyyuru SK, et al. - In patients with acute severe ulcerative colitis (ASUC), researchers conducted this open‐label randomized controlled trial to examine the efficacy of exclusive enteral nutrition (EEN) as adjunctive therapy to intravenous corticosteroids. Patients who were admitted between August 2018 and May 2020 with ASUC were randomized 1:1 to EEN or standard of care (SOC). There were 32 randomized to EEN and 30 to SOC out of a total of 62 patients (mean age 35.3 ± 12.1 years, 40% male). Compared with SOC, corticosteroid failure was lower on EEN; there was no difference in the rate of colectomy. EEN patients had a shorter hospital stay, higher albumin level on day 7, a greater decrease in serum C-reactive protein and fecal calprotectin levels, and a lower colectomy/hospitalization composite result at 6 months vs SOC. Relative to SOC, the EEN patients displayed an increased abundance of Erysipelotrichaceaeon day 7, with decreased Bifidobacterium and Veillonellaceae.