Zhang X, et al. - In this case-cohort study involving 79,705 postmenopausal women aged 50-79 years, authors analyzed the racial/ethnic disparities in circulating levels of 25-hydroxyvitamin D and parathyroid hormone in relation to cardiovascular disease (CVD) risk. Specifically, they measured and assessed vitamin D–binding protein, total 25(OH)D, parathyroid hormone, and albumin levels, and calculated free and bioavailable 25(OH)D. No significant relation was observed between vitamin D–binding protein and total, free, and bioavailable 25(OH)D and CVD risk in black or white females. However, they did note that a significant positive correlation between parathyroid hormone and CVD risk persevered in white but not black women, independent of total, free, and bioavailable 25(OH)D or vitamin D–binding protein. The authors, therefore, suggested that higher parathyroid hormone levels may be an independent risk factor for CVD in white women.