Rajeshuni N, et al. - Using the Surveillance, Epidemiology, and End Results 18 Registries, researchers performed this retrospective multicenter population-based cohort study, to define the influence of race, ethnicity, and census tract–level composite socioeconomic status (SES) on retinoblastoma enucleation. This inquiry augments Truong and associates, offering multivariate analyses merging sociodemographic and clinical features with more precise SES measures. The presence of increased adjusted odds of enucleation was hypothesized in children from nonwhite, Hispanic, and lower socioeconomic backgrounds. The study sample comprised children, aged 18 years and younger, who received the diagnosis of retinoblastoma between 2000 and 2014. Of 959 retinoblastoma patients, 70.8% were enucleated. Older age at diagnosis, unilateral disease, and advanced stage were related to a significantly increased enucleation risk. Findings revealed more probability of receiving enucleation in children from nonwhite, Hispanic, and lower socioeconomic backgrounds. These links were found to be independent of stage of diagnosis, implying larger systemic variations in retinoblastoma care.