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Racial disparities in eligibility for preemptive waitlisting for kidney transplantation and modification of eGFR thresholds to equalize waitlist time

Journal of the American Society of Nephrology Feb 27, 2021

Ku E, McCulloch CE, Adey DB, et al. - Under current US national policy, wait time for kidney transplantation may be accrued by patients when their eGFR is ≤ 20 ml/min. However, kidney disease progresses more rapidly among Black patients than White patients, which may result in disparities in accruable time on the kidney transplant waitlist before dialysis initiation. Differences in accruable wait time and transplant preparation were compared by CKD-EPI determining equations in Chronic Renal Insufficiency Cohort participants, on the basis of measures of kidney function by creatinine (eGFR cr ), cystatin C (eGFR cys ), or both (eGFR cr-cys). The correlation between race (non-Hispanic Black or non-Hispanic White) and time to ESKD from an eGFR of ≤ 20 ml/min per 1.73 m 2 was determined by using Weibull accelerated failure time models. Findings suggest that this time was shorter for Black vs White patients. Per estimates, allowing registration of Black patients on the transplant waitlist at higher levels of kidney function (as early as an eGFR of 24–25 ml/min per 1.73 m2) compared with White patients could theoretically reduce differences in accruable wait time and improve racial equity in transplant access.

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