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Race and ethnicity predict bone markers and fracture in pediatric patients with chronic kidney disease

Journal of Bone and Mineral Research Feb 20, 2021

Laster M, Denburg M, Okuda Y, et al. - This study was carried out to evaluate the impact of race and ethnicity on bone markers and fractures within the pediatric chronic kidney disease (CKD) population. Researchers conducted a cohort study including a total of 762 children between the ages of 1.5 years and 18 years, with CKD, stages 1 to 4 from the CKD in children (CKiD) cohort, the relationship between the racial‐ethnic group and bone markers (parathyroid hormone [PTH], 25‐hydroxyvitamin D [25‐OHD], 1,25‐dihydroxy vitamin D [1,25(OH)2D], and C‐terminal fibroblast growth factor [FGF23]) was ascertained by applying linear mixed models. In the CKD population, the current findings are similar to racial‐ethnic differences described in healthy children. Future research is required to better understand how these variations might impact the management of pediatric CKD‐MBD.

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