Avery RK, Motter JD, Jackson KR, et al. - Researchers investigated the risk of infections in relation to receiving desensitization among patients undergoing incompatible living donor kidney transplantation (ILDKT). They analyzed 475 recipients, grouped by desensitization intensity: none/compatible (n = 260), low (0‐4 plasmaphereses,n = 47), moderate (5‐9,n = 74), and high (≥10,n = 94). For recipients who received none, low, moderate, and high intensity desensitization, the 1‐year cumulative incidence of infection was estimated to be 50.1%, 49.8%, 66.0%, and 73.5%, respectively. UTI, opportunistic, and bloodstream were reported as the most common infections. Low and moderately desensitized recipients demonstrated a trend towards increased risk in weighted models, with a statistically significant 2.22‐fold raised risk noted in highly desensitized recipients. Findings showed a more common occurrence of post‐KT infections in desensitized ILDKT recipients. An ultra‐high risk for infections was observed in a subset of highly desensitized patients.