Sagara I, et al. - The efficacy and safety of pyronaridine–artesunate and dihydroartemisinin–piperaquine were comparatively analyzed with the current first-line treatment in the case of uncomplicated malaria, performed at 7 tertiary centres in Burkina Faso, Guinea, and Mali. The inclusion criteria involved adults and children aged 6 months and older with microscopically confirmed Plasmodium spp malaria (>0 to <200,000 parasites per μL of blood) and fever or history of fever in the previous 24 h. It was discovered that pyronaridine–artesunate and dihydroartemisinin–piperaquine treatment and retreatment of malaria were well tolerated, displaying an efficacy that was non-inferior to first-line artemisinin-based combination therapies. Yielded data justified greater access to these efficacious treatments in West Africa.