Jensen J, et al. – The goal of this research was to confirm the observation that pulmonary artery (PA) enhancement is often decreased in sickle cell disease (SCD) patients imaged with MDCT for suspected pulmonary embolism and determine whether contrast infusion parameters are accountable for lower enhancement levels. It was noted that main PA enhancement level was lower than controls in this series of adult SCD patients with suspected PE imaged with MDCT. Remarkably, quality improvement investigations should focus on protocol optimization to improve enhancement quality and likelihood of a definitive diagnosis.