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Psychiatric disorders in children and adolescents conceived by assisted reproductive techniques

JAMA Feb 05, 2022

Relative to the general population, adolescents conceived with assisted reproductive technique (ART) are not at risk of poor psychiatric health, except for an increased risk of obsessive-compulsive disorder (OCD) that could be explained by disparities in parental characteristics.

  • In this long-term follow-up of a Swedish birth cohort of 1,221,812 children, researchers focused on the risk of psychiatric disorders in adolescents and young adults conceived with ARTs and assessed the role of treatment-related parental characteristics.

  • An increased risk of OCD (hazard ratio, 1.35) was present in adolescents conceived with ARTs vs all other children.

  • Those conceived with ARTs had no elevated risk of any other types of anxiety, depression, or suicide compared with all other children.

  • OCD risk no longer existed in comparison with children born to couples with infertility.

  • No association was found between the type of fertilization (standard in vitro fertilization or intracytoplasmic sperm injection) and outcomes.

  • Relative to non–ART-conceived children of couples with infertility, fresh, but not frozen, embryo transfer was identified to be linked with a lower risk of mood disorders, making frozen embryo transfer seem less beneficial when directly compared with fresh embryo transfer.

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