Cao C, et al. – The purpose of this trial was to illustrate the hypothesis that the atypical forms of asthma such as cough variant asthma (CVA) or chest tightness variant asthma (CTVA) exhibited distinctive cellular and molecular features. It was deduced that patients with classical asthma, CVA, or CTVA shared common clinical characteristics of eosinophilic airway inflammation. Their sputum samples were composed of common factors with minor distinctions. These three different presentations of asthma reported a similar pathogenetic mechanism, with regard to an enhanced Th2 associated with eosinophilia, which was validated in this research. It also detected a pool of novel biomarkers for diagnosis of asthma and to label its subtypes.