Valdez-Flores RA, et al. - In patients undergoing transrectal ultrasonography (TRUS)-guided prostate biopsy, the efficacy and safety of three intrarectal local anesthesia (IRLA) combined with periprostatic nerve block (PPNB) was examined by the authors. When applied in combination with PPNB, intrarectal application of prilocaine/lidocaine (EMLA) cream was more effective in reducing pain than either 2% lidocaine gel or 100 mg indomethacin suppository. For the patients undergoing TRUS-guided prostate biopsy, this combination served as an effective option for pain relief.