Aguayo GA, Hulman A, Vaillant MT, et al. - Using mixed-effects models with age as a time scale, researchers ascertained if people with overt diabetes or higher levels of HbA_1c or fasting plasma glucose experience different frailty trajectories with aging. Of the 5,377 participants in this study (median age: 70years; 45% men), 35% were baseline frail. Throughout later life, individuals with diabetes or higher HbA_1c levels at baseline had a higher frailty level. In addition, non-frail participants with diabetes or higher HbA_1c felt more rapid deterioration of frailty level with aging. This observation may reflect the role of complications of diabetes in frailty trajectories or earlier shared determinants that contribute to later life's diabetes and frailty risk. Only diabetes was associated with an increased frailty index in a model additionally adjusted for income, social class, smoking, alcohol, and hemoglobin.