Coors SM, et al. - The proposition explored during this study was that prophylactic dextrose gel administered to newborn infants at risk for hypoglycemia would increase the initial blood glucose concentration after the first feeding and decrease Neonatal Intensive Care Unit (NICU) admissions for the treatment of asymptomatic neonatal hypoglycemia compared with feedings alone. A reduction was not achieved in the transient neonatal hypoglycemia or NICU admissions for hypoglycemia through prophylactic dextrose gel. It was reported that the carbohydrate concentration of Insta-Glucose (77%) possibly led to a hyperinsulinemic response, or alternatively, exogenous enteral dextrose minimally affected glucose homeostasis during the first few hours when counter-regulatory mechanisms were particularly active.