Dourado MR, Miwa KYM, Hamada GB, et al. - In order to find out the prognostic significance of those histological parameters, individually and in combination, for oral squamous cell carcinomas (OSCC), researchers included a sum of 254 individuals with OSCC to calculate tumor-stroma ratio (TSR) and tumor budding (the presence of ≥ 5 buds at the invasive front). By using a chi-square test, clinicopathological correlations were examined, and by Kaplan-Meier analysis and the Cox proportional hazard model, the prognostic significance (cancer-specific survival and disease-free survival) was verified. The significant information was provided by TSR, tumor budding and their combination on OSCC outcome, implying that their incorporation into the routine investigation of histopathological specimens might be beneficial in the prognostication of OSCC individuals.