Oike F, Usuku H, Yamamoto E, et al. - Findings demonstrate a significant prognostic value of left atrial strain during the reservoir phase in patients suffering from wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), even post-adjusting for traditional predictive factors.

• This study included 113 patients with ATTRwt-CM.

• The cardiovascular death group had a higher rate of a V1–V3 QS pattern and complete left bundle branch block (electrocardiographic findings) vs in the non-event group.

• On echocardiography, a significantly lower peak left atrial (LA) strain rate during the contraction phase, LA strain during the reservoir phase (LASr), and peak LA strain rate during the reservoir phase was detected in the cardiovascular death group vs in the non-event group.

• In patients with ATTRwt-CM, there was a significant and independent association of LASr with cardiovascular death, post-adjustments.

• Area under the curve of LASr for cardiovascular mortality was 0.686 and the best cut-off value of LASr was 6.69% (sensitivity, 62.4%; specificity, 64.3%).

• A significantly higher likelihood of total cardiovascular death and heart failure-related hospitalization was observed in patients with low LASr (<6.69%).