Lin YW, Jiang M, Wei XB, et al. - To determine whether D-dimer is prognostically valuable in patients with infective endocarditis (IE), this study was undertaken with 613 patients with IE who were split into two groups based on the cut-off of D-dimer ascertained via receiver operating characteristic curve analysis for in-hospital death: > 3.5 mg/L (n = 89) and ≤ 3.5 mg/L (n = 524). Significantly higher in-hospital death, embolism, and stroke were detected in patients with D-dimer > 3.5 mg/L vs in those with D-dimer ≤ 3.5 mg/L. According to the Kaplan–Meier curve, patients with D-dimer > 3.5 mg/L experienced significantly higher cumulative 6-month mortality compared with those with D-dimer ≤ 3.5 mg/L. Findings revealed an independent association of D-dimer with in-hospital adverse events as well as six-month mortality in patients with IE, and D-dimer was concluded to be a dependable prognostic biomarker in these patients.