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Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor-infiltrating immune cell analysis

Cancer Medicine May 28, 2021

Wan Y, Wang X, Liu T, et al. - In an attempt to unveil prognostic indicators in lung adenocarcinoma (LUAD), researchers herein analyzed 551 LUAD samples to compute the scores of stromal and immune components of the tumor microenvironment employing the ESTIMATE algorithm on The Cancer Genome Atlas database. A positive correlation of the ImmuneScore with prognosis regarding survival rate, T classification of TNM stages, and clinicopathological staging characteristics, was identified. In the PPI network and Cox proportional hazards regression analysis, 3 genes of LUAD were selected. According to Lasso regression analysis, the most survival correlated gene was CC chemokine receptor 2 (CCR2). Overall, findings demonstrated the prognostic value of CCR2 as an immune indicator in LUAD.

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