Wang C, Cui T, Wang L, et al. - Given the neuroprotective effect of uric acid (UA), an important endogenous free radical scavenger, researchers here examined if there is a correlation between UA change and outcome in acute ischemic stroke (AIS) patients with reperfusion therapy. They included 361 AIS patients with reperfusion therapy (mean age 68.7 ± 13.9 years, 54.3% males) and assessed them for UA measures at admission and during hospitalization. At admission, the mean UA was 355 ± 96.1 μmol/L. The patients had median ΔUA of 121 μmol/L (IQR 50‐192 μmol/L) and increased UA levels were observed in 18 (5%) patients. Observations revealed correlation of high UA on admission with a good 3‐month outcome among patients with reperfusion therapy; poor outcome was reported in correlation with a greater reduction in UA.