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Prognostic significance of insulin resistance in pulmonary hypertension

ESC Heart Failure Dec 21, 2021

Zare E, Kafshbani P, Chenaghlou M, et al. - In pulmonary hypertension (PH), dysregulation of glucose metabolism occurs, and insulin resistance (IR) may elevate the risk of adverse events in these patients.

  • In this study of 59 non-diabetic PH patients, 27% had IR considering the Iranian cut points of homeostasis model assessment of insulin resistance.

  • In non-diabetic, non-metabolic syndrome patients with precapillary PH, IR prevalence was higher (34.2%) vs that in non-diabetic, non-metabolic syndrome Iranian population (24.1%).

  • Death rate in the follow-up period was 44.1%.

  • A slightly lower survival was noted in IR patients vs insulin sensitive patients; however, IR was not an independent predictor of death.

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