Lee KH, Suh HY, Lee MW, et al. - Survival outcomes can be predicted via epidermal growth factor receptor (EGFR) immunostaining in distant metastatic melanoma. The EGFR expression in distant metastatic melanoma in male, no ulcer, or Breslow thickness ≤4.0 mm seemed to be involved in disease progression.

• This retrospective study involved 55 cases of distant metastatic melanoma.

• EGFR expression was determined via immunohistochemistry analysis of diagnostic tissues.

• In distant metastatic melanoma, a significant correlation of positive EGFR expression with the absence of ulceration was evident.

• EGFR expression was significantly related to poor survival, under the conditions of male gender and primary cutaneous melanoma without ulceration or Breslow thickness ≤4.0 mm.