León X, et al. - In patients with human papillomavirus-negative (HPV-negative) head and neck squamous cell carcinoma (SCC) treated with a planned neck dissection after chemoradiotherapy, researchers assessed the prognostic value of nodes with extracapsular spread (ECS). This was a retrospective study of 109 cN+ patients who achieved a complete response in the primary location with this treatment. Identification of a group of patients with a high risk of failure was allowed by the of ECS in the pathologic study of these patients. The 5-year disease-specific survival for patients without residual metastatic nodes in the neck dissection was 75.7%; for patients with metastatic nodes without ECS, it was 74.0%, and for patients with metastatic neck nodes with ECS it was 8.7%.