Xiong H, Gao H, Hu J, et al. - This study was intended to construct a clinically translatable immune-related gene pairs (IRGPs) prognostic signature to estimate the overall survival of bladder cancer. Thirty-seven prognostic-related IRGPs were distinguished using LASSO regression from the 251 prognostic-related IRGPs. Researchers distinguished IRGPs with the potential to be prognostic markers. The findings demonstrated that immune cells correlated with poor prognosis of bladder cancer (BC) were upregulated in the high-risk score group, whereas immune cells associated with a better prognosis of BC were downregulated in the high-risk score group. The findings suggested that other immunoregulatory genes were also differentially expressed between high and low-risk score groups. In this study, a 37 IRGPs-based risk score signature is presented.