Pun SC, et al. - Analysts assess the prognostic implication of baseline global longitudinal strain (GLS) and the added value of GLS beyond circulating cardiac biomarkers for risk stratification in patients with light-chain (AL) amyloidosis undergoing hematopoietic cell transplantation (HCT). The current study showed that the GLS is a strong predictor of survival in patients with AL amyloidosis undergoing HCT, potentially providing incremental value over serum cardiac biomarkers for risk stratification. GLS ought to be considered as a standard parameter along with serum cardiac biomarkers when assessing eligibility for HCT or other investigational therapies.