Yoon JH, et al. - Researchers evaluated patients with culture-negative liver abscess (CNLA) vs those with a positive culture (CPLA) regarding the clinical and prognostic differences. In addition, they assessed these factors for K. pneumoniae liver abscess (KLA) vs E. coli liver abscess (ELA). A total of 402 patients with liver abscess who were admitted at two tertiary hospitals in Korea from 2012 to 2016 were included. Positive cultures were reported for 61.2% of these. The most common cause was K. pneumoniae (n = 133), followed by E. coli (n=74). Observations revealed CNLA patients and CPLA patients have a comparable prognosis. Compared to patients with CNLA, patients with CPLA were significantly older and had cholelithiasis or biliary tract disease more often and had a significantly longer length of hospital stay. Patients with ELA more frequently had cholelithiasis, or biliary tract disease, liver disease, malignancy, and ESBL production vs those with KLA.