Santos-Lima EKN, et al. - Authors examined the in vitro production of interferon-gamma (IFN-γ), interleukin (IL)-6, and IL-1β cytokines due to antigenic stimulation of peripheral blood mononuclear cells (PBMCs) with novel lys-gingipain (Kgp) synthetic peptides. They observed that Kgp12, 17, and 18 peptides caused lower production of IFN-γ. They also found the induction of higher levels of IFN-γ due to Kgp12 in cases without periodontitis (WP) when compared to subjects with periodontitis (P). Higher production of IL-6 and IL-1β was noted due to Kgp12 as compared with other stimuli.