Liao W, Chen C, Wen T, et al. - By integrating the latest research evidence in this meta-analysis, researchers examined the impact of probiotics on preventing antibiotic-associated diarrhea (AAD) in adults. Relevant randomized placebo-controlled trials were identified from PubMed, Cochrane Library, EMBASE, and Web of Science. Experts analyzed 36 studies including 9,312 participants. A reduction in the incidence of AAD by 38% was brought about by probiotics. When categorized by causes for antibiotics treatment, probiotic duration, probiotic dosage, and time from antibiotic to probiotic, the protective impact of probiotics was still found to be significant. In the probiotics group, no statistically significant increased adverse events were reported. According to the findings of this updated meta-analysis, probiotics, when used as early as possible during antibiotic treatment, were shown to have a positive as well as a safe impact on preventing AAD in adults.