Midorikawa Y, Takayama T, Nakayama H, et al. - Researchers conducted this retrospective cohort study to ascertain if prior HBV infection (PBI) impacts the clinical results of patients undergoing liver resection for hepatitis C virus (HCV)-related HCC. According to results, the median overall survival of 165 PBI patients (defined as those negative for hepatitis B surface antigen and positive for anti-hepatitis B core antibody) in the HCV group was 4.7 years, this was significantly shorter than that seen in 263 PBI-free patients. In multivariate analysis, PBI, multiple tumors, tumor size, and liver cirrhosis were independent factors for overall survival. Investigators discovered that PBI was an unfavorable prognostic factor that had a negative impact on survival rates for HCV-related HCC after liver resection; it did not impact surgical results in non-B non-C HCC patients. The results indicate that PBI and HCV together influence survival in patients who have undergone HCC resection.