Thiruganasambandamoorthy V, et al. - Combining data from two large prospective studies that enrolled adults with syncope from 17 emergency departments (EDs) in Canada and the United States, researchers evaluated the prevalence of pulmonary embolism among ED patients with syncope. This analysis included 9,091 patients with 30-day follow-up: 547 (6.0%) were evaluated for pulmonary embolism (278 [3.1%] had D-dimer, 39 [0.4%] had ventilation-perfusion scan, and 347 [3.8%] had CT pulmonary angiography). Outcomes revealed a very low prevalence of pulmonary embolism among the ED patients with syncope, including those hospitalized after syncope. The investigators recommended that clinicians practice caution regarding indiscriminate investigations for pulmonary embolism despite a possible involvement of an underlying pulmonary embolism in causing syncope.