Manniche C, Stokholm L, Ravn SL, et al. - This study was undertaken to investigate the prevalence and long-term use of prescribed opioids in patients of the Spinal Pain Opioid Cohort. In this cohort, a total of 8,356 patients were enrolled, 4,409 (53%) had one or more opioid prescriptions in the registered nine years period. This study’s findings indicated that previous opioid treatment—i.e., before a new acute spinal pain episode and referral to a Spine Center—doubled the risk of long-term opioid therapy 5 years later. According to the findings, outcomes underscore clinicians' obligation to carefully and individually weigh the advantages against the risks of prescribing opioid therapy.