Eusebi LH, et al. – This meta–analysis aimed to evaluate the prevalence of dyspepsia in individuals with gastro–esophageal reflux symptoms (GERS), and to quantify overlap between the disorders. In individuals with weekly GERS, the odds of dyspepsia was almost 7–fold that of individuals without GERS; dyspepsia and GERS overlap in more than 25% of individuals. Reasons for this remained speculative but might include shared pathophysiological mechanisms or residual confounding factors. However, to optimize treatment approaches, patients with GERS had to be questioned about co–existent dyspepsia.