Sinha S, Singh RB, Dohlman TH, et al. - Researchers conducted the study for determining the prevalence and risk factors associated with corneal perforation in patients with chronic ocular graft-versus-host disease (oGVHD). Over an 8-year period, the authors at a single academic center reviewed the case records of 405 patients diagnosed with chronic oGVHD and evaluated the prevalence of corneal perforation in the cohort. A corneal perforation occurred in 15 (3.7%) of the 405 patients with chronic oGVHD. Data reported that the median time to corneal perforation was 3.3 years post-hematopoietic stem cell transplantation. Chronic oGVHD can cause corneal perforation, which is a rare but vision-threatening condition. Regardless of the severity of the disease, the study underscores the importance of frequent and long-term follow-up of patients with oGVHD. Patients with chronic oGVHD who are taking topical antiglaucoma drugs should be regularly monitored since they have an increased risk of corneal perforation.