Blum M, Cao D, Chandiramani R, et al. - This investigation involved men and women undergoing percutaneous coronary intervention (PCI), in whom the prevalence and prognostic influence of high-sensitivity C-reactive protein (hsCRP) elevation was investigated according to age. This study involved 10,432 men and 4,345 women. A total of 25.7% of men and 37.0% of women exhibited hsCRP elevation. Across age strata, a stable prevalence of hsCRP elevation was seen in males. In females, those <50 years (44.6%) had the highest prevalence of hsCRP elevation, and a stepwise decrease in prevalence was seen with increasing age. Post-stratification of participants into age quartiles (Q1: <59 years, Q2: 59–66 years, Q3: 67–74 years, Q4: ≥75 years), elevated risk of major adverse cardiac events (MACE) in relation to hsCRP elevation was observed across all age groups in males. hsCRP elevation in females was related to elevated risk of MACE only in older patients. Overall, hsCRP elevation prevalence as well as its prognostic value in patients receiving PCI were shown to be age-dependent exclusively in females.