Ogari CO, et al. - In this cross-sectional study, the prevalence of mutations responsible for drug resistance in Mycobacterium tuberculosis among 132 tuberculosis (TB) positive patients visiting Mbagathi and Chandaria hospitals was determined. Transmission of the drug-resistant M. tuberculosis strains was confirmed in molecular analysis. Overall, they observed resistance prevalence of 1.5% (2/132) to first and second-line TB drugs. They detected mutations for the multi-drug resistant tuberculosis (MDR-TB) ie, katG S513 T for INH, rpoB S531 L for rifampicin (RIF) and rrs G1484 T for cross-resistance to aminoglycosides/capreomycin (AG/CP) whereas the isoniazid (INH) resistant strain showed the katG mutations S315 T. Findings emphasize that among patients infected with TB, drug resistance surveillance and drug adherence need to be intensified