Pretreatment antimüllerian hormone levels and outcomes of ovarian stimulation with gonadotropins/intrauterine insemination cycles
Fertility and Sterility Apr 08, 2021
Vagios S, Hsu JY, Sacha CR, et al. - Researchers undertook a retrospective cohort study with the aim to examine if serum antimüllerian hormone (AMH) levels are associated with probability of clinical pregnancy and spontaneous abortion (SAB) in the infertility setting. They assessed a total of 1,861 gonadotropin stimulation/intrauterine insemination cycles and stratified them by AMH levels into 3 groups: Low, < 25th percentile (< 0.7 ng/mL); Middle, ≥ 25th and < 75th percentile (0.7–4.4 ng/mL); and High, ≥ 75th percentile (≥ 4.5 ng/mL). Overall, in both unadjusted and adjusted models, the Middle and High AMH groups showed higher probability of achieving a clinical pregnancy compared with that noted in the Low AMH group, both over 3 and 6 cycles. Per findings, AMH seemed to influence the probability of achieving a clinical pregnancy in women undergoing gonadotropin stimulation/intrauterine insemination. In addition, they suggested a possible negative impact, independent of age, on the risk of SAB.
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