Mangalesh S, Sarin N, McGeehan B, et al. - Researchers conducted the study for comparing stress during investigational optical coherence tomography (OCT) imaging to that during binocular indirect ophthalmoscopy (BIO) for retinopathy of prematurity (ROP). Several indicators of behavioral stress (crying and facial expression) and physiologic stress (heart rate) were lower during OCT imaging than during BIO in this cross-sectional study of 71 eye examinations of 16 infants, despite the longer time for OCT imaging. OCT imaging and BIO did not show any differences in respiratory rate or oxygen saturation. Although the role of OCT alone or in combination with BIO for ROP is uncertain at this time, these results indicate that investigational OCT imaging of ROP is less stressful than BIO examination by a trained ophthalmologist.