Winger EE, et al. - This trial incorporated an analysis of the capacity of immune cell microRNAs isolated from peripheral blood in the first trimester, with the intention of examining their ability to speculate preeclampsia, preterm birth and miscarriage. The yielded data validated that the Great Obstetrical Syndromes displayed a common biological origin early in the first trimester, possibly identified throughout the first trimester using peripheral blood cell microRNA. The study utilized microRNA in peripheral blood immune cells to successfully predict multiple placental bed related pregnancy disorders with high sensitivity and specificity. Early assessment permitted the use with other new first trimester screening methods, such as NIPT. Hence, comprehensive risk assessment package could be presented to the patient.