Nguyen CV, He Q, Rady PL, et al. - Researchers investigated the prevalence and type of detectable human papillomavirus (HPV) DNA in voriconazole-associated squamous cell carcinoma (SCC). They evaluated HPV DNA using PCR analysis in SCCs from immunosuppressed patients, in those with and without voriconazole exposure, and compared these with SCC from non-immunosuppressed patients. Regardless of the immunosuppression status, HPV DNA was identified in all groups (80.5%) with beta HPV most prevalent (64.3–78.6%). However, they identified a significantly higher likelihood to be infected by beta HPV types 5, 8, 14, 20, and 21 among immunosuppressed patients, and these represented the majority of beta HPV types obtained in the voriconazole group. These findings suggest a possible role of beta HPV in the pathogenesis of cutaneous SCC in photo-exposed areas.