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Preoperative predictors of early mortality risk in isocitrate dehydrogenase-wild-type glioblastoma patients treated with standard therapy

Cancer Management and Research Feb 11, 2021

Zhao C, Li L, Guo X, et al. - For isocitrate dehydrogenase (IDH) -wild-type (wt) glioblastoma (GBM) patients, researchers aimed at determining the preoperative factors linked with higher risk of early death (within 1 year after surgery). In this retrospective analysis of 194 IDH-wt GBM patients who underwent standard treatment, they observed 1‐year mortality rate of 21.6%. Independent predictors for 1‐year mortality following GTR included tumor location, preoperative elevated NLR and serum LDH level. Per findings, a greater preoperative NLR or LDH may guide patients to review head MRI more frequently and regularly to monitor tumor progression.

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