Fasmer KE, Gulati A, Dybvik JA, et al. - In this study, the diagnostic accuracy of preoperative 18F-FDG PET/CT and MRI tumor markers for prediction of lymph node metastases (LNM) and aggressive disease in endometrial cancer (EC) were compared. Researchers conducted preoperative whole-body 18F-FDG PET/CT and pelvic MRI in 215 consecutive individuals with histologically confirmed EC. In this imaging study, PET/CT-based tumor standardized uptake value, metabolic tumor volume (MTV), and PET-positive lymph nodes (LNs) were examined together with the MRI-based tumor volume (VMRI), mean apparent diffusion coefficient (ADCmean), and MRI-positive LN (maximum short-axis diameter ≥ 10 mm). For the prediction of LNM, tumor markers from 18F-FDG PET/CT outperform MRI markers. In endometrial cancer, MTV > 27 ml yields a high diagnostic performance for predicting aggressive disease and serves a promising supplement to conventional PET/CT reading.