Ligon C, Shah A, Prasad M, et al. - Findings suggest no added predictive value of adding measured β-cell function to defined clinical models of diabetes remission 1 year after surgical weight loss in individuals with type 2 diabetes. Individuals with type 2 diabetes show improvement in glycemic control after undergoing bariatric surgery.

• Seventy three individuals with severe obesity and type 2 diabetes were assessed for pre surgery clinical characteristics, metabolic markers, and β-cell function after oral and intravenous (IV) glucose challenges; assessment was again performed 1 year after gastric bypass surgery.

• A negative correlation of presurgery β-cell glucose sensitivity, a surrogate of β-cell function, was observed with known diabetes duration, HbA1c, insulin use, and the diabetes remission scores DiaRem and advanced (Ad)-DiaRem.

• Estimates indicated 1.6-fold greater β-cell function after oral glucose than after the IV glucose challenge and the measures of β-cell function more strongly linked with preoperative clinical and metabolic characteristics.

• Clinical models containing well-defined diabetes remission scores showed no improvement in their ability to predict diabetes remission after Roux-en-Y gastric bypass, when preoperative β-cell function is added to them.