Markwei MT, Babatunde I, Rathi N, et al. - Researchers aimed at systematically reviewing the relative effectiveness of preincision cefazolin with or without adjunctive prophylaxis (macrolides or metronidazole) vs cefazolin alone in lowering the incidence of postcesarean delivery surgical site infections. Searching PubMed, Ovid EMBASE, Google Scholar, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials, they identified 3 randomized controlled trials and 1 prospective observational study representing 2,613 women, for inclusion in this work. The findings support using preincision adjunctive extended-spectrum prophylaxis with cefazolin over cefazolin alone, as there were significant reductions in surgical site infections (relative risk, 0.46; 95% confidence interval, 0.34–0.63; 3 randomized controlled trials) and the duration of hospital stay (weighted mean difference, −1.46; 95% confidence interval, −2.21 to −0.71; 2 randomized controlled trials) with preincision cefazolin and adjunctive prophylaxis vs cefazolin alone.