Rugeri L, Desage S, Khouatra L, et al. - Researchers compared women with protein C (PC) deficiency vs patients with heterozygous factor V Leiden mutation, in terms of the risk of pregnancy related-venous thromboembolism. This investigation included prospectively enrolled 145 consecutive pregnant women having verified PC deficiency or heterozygous factor V Leiden mutation. To individually tailor antithrombotic prophylaxis, Lyon venous thromboembolism-risk score was employed. Findings revealed that the occurrence of venous thromboembolism did not differ between pregnant women with PC deficiency and those with heterozygous factor V Leiden. Considering the findings, experts recommended that low-molecular-weight heparin prophylaxis should not be compulsory in all pregnant women having PC deficiency. Similar prevention approaches may be implemented in women with factor V Leiden mutation or PC deficiency.