Sherer ML, Lei J, Creisher P, et al. - Researchers herein examined how SARS-CoV-2 infection during pregnancy affects inflammatory and humoral responses in maternal and fetal samples. In addition, they compared antibody responses to SARS-CoV-2 among pregnant and non-pregnant women. Assessment of immune responses to SARS-CoV-2 was done in samples obtained from pregnant (n = 33) and non-pregnant (n = 17) women who had either tested positive (pregnant n = 22; non-pregnant n = 17) or negative for SARS-CoV-2 (pregnant n = 11) at Johns Hopkins Hospital. Blood samples collected within 14 days vs > 14 days after a confirmed SARS-CoV-2 test from SARS-COV-2 positive pregnant women showed more expression of IL1β, but not of IL6. Placental inflammation and reduced antiviral antibody responses characterized SARS-CoV-2 infection during pregnancy, these characteristics may influence the efficacy of COVID-19 therapeutics in pregnancy. Greater consideration is also required for the long-term implications of placental inflammation for neonatal health.