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Preeclampsia is a valuable opportunity to diagnose chronic kidney disease: A multicentre study

Nephrology Dialysis Transplantation Aug 05, 2021

Cabiddu G, Mannucci C, Fois A, et al. - The prevalence of newly diagnosed chronic kidney disease (CKD) is high in a large multicenter cohort of women without acknowledged CKD who experienced a preeclampsia (PE) (19% vs expected 3% in women in childbearing age). This supports a systematic nephrology work-up after PE.

  • The KDOQI guidelines were followed to define CKD; urinary alterations or low eGFR confirmed at least 3 months of distance, or morphologic changes.

  • Division of patients into 4 groups was done: evidence of CKD; no evidence of CKD; unclear diagnosis-ongoing work-up; persistent microalbuminuria.

  • France (Le Mans, Central France) and Italy (Cagliari, Sardinia) were identical in incidence of CKD diagnosis (Le Mans: 19.1%; Cagliari: 19.2%) and had no significant difference in unclear-ongoing diagnosis (6.2%; 5.8%) and microalbuminuria (10.5%; 5.8%).

  • There were more frequent occurrences of glomerulonephritis and diabetic nephropathy in Cagliari (higher age and diabetes prevalence) and interstitial diseases in Le Mans.

  • Patients diagnosed with CKD had one week shorter gestation.

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